Table 2.
Diversity of the posttranscriptional Csr(Rsm) regulatory module of the Gac-Rsm cascade in the genus Pseudomonas.
| Pseudomonas species—strain | Additional factors controlling Gac-Rsm cascade | CsrA homolog(s) | Molecular mimic sRNA(s) | Controlled phenotypes | References |
|---|---|---|---|---|---|
| P. aeruginosa PAO1 | LadS, RetS and PA1611 histidine kinases | RsmA, RsmN (RsmF) | RsmY, RsmZ, RsmW (Gac-independent), RsmV (Gac-independent) | Quorum sensing; virulence factors, sessile-to-biofilm switch | Ventre et al., 2006; Marden et al., 2013; Morris et al., 2013; Chambonnier et al., 2016; Miller et al., 2016; Schulmeyer et al., 2016; Janssen et al., 2018; Romero et al., 2018 |
| P. brassicacearum NFM421 | Unknown | RsmA, RsmE | RsmX, RsmY, RsmZ | Antibiotics, indole acetate, extracellular enzymes, quorum sensing, T6SS, alginate, biofilm | Lalaouna et al., 2012 |
| P. chlororaphis 30-84 | Unknown | RsmA, RsmE | RsmX, RsmY, RsmZ | Biosynthesis of phenazines, quorum sensing, extracellular enzymes | Chancey et al., 1999; Wang et al., 2013 |
| P. donghuensis HYS/SVBP6/P482 | Unknown | RsmA, RsmE, Rsm3 | RsmY, RsmZ | Biosynthesis of 7-hydroxytropolone, antifungal activity, production of HCN and other volatile compounds | Yu et al., 2014; Ossowicki et al., 2017; Agaras et al., 2018; Chen et al., 2018; Muzio et al., 2020 |
| P. entomophila Pe | Unknown | RsmA1, RsmA2, RsmA3 | RsmY, RsmZ | Insect virulence factors, exopotease, lipopeptide | Vodovar et al., 2006; Vallet-Gely et al., 2010 |
| P. fluorescens SS101 | Unknown | RsmA, RsmE | RsmY, RsmZ | Lipopeptide, iron acquisition, motility, chemotaxis T6SS | Song et al., 2015 |
| P. protegens CHA0 | Temperature, ppGpp, Krebs cycle intermediates, LadS, RetS | RsmA, RsmE | RsmX, RsmY, RsmZ | Biocontrol properties (antifungal compounds, HCN, extracellular enzymes, lipopeptide) | Heeb et al., 2002; Valverde et al., 2003; Reimmann et al., 2005; Humair et al., 2009; Takeuchi et al., 2009; Workentine et al., 2009; Sobrero et al., 2017 |
| P. putida KT2440 | Unknown | RsmA, RsmE, RsmI | RsmY, RsmZ, RsmX? | Motility, biofilm formation (LapA adhesin) | Martinez-Gil et al., 2014; Huertas-Rosales et al., 2016 |
| P. syringae pv syringae DC3000 | LadS, RetS | CsrA1 (RsmI), CsrA2 (RsmA), CsrA3 (RsmE), CsrA4, CsrA5 | RsmX1-5, RsmY, RsmZ | Carbon metabolism, virulence, motility, production of secondary metabolism, quorum sensing | Moll et al., 2010; Records and Gross, 2010; Ferreiro et al., 2018 |