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. 2020 Jul 10;8:611. doi: 10.3389/fcell.2020.00611

TABLE 1.

Summary of adhesion molecules expressed on hematopoietic stem cells and their counter receptors on niche components.

Sr. no. Adhesion molecules on HSCs Receptor molecules in niche Niche component expressing receptor molecules References
1 Integrin β1αL (LFA-1) ICAM-1 Endothelial cells Shimizu et al., 1990
2 Integrin β1α4 (VLA-4) VCAM-1/fibronectin Endothelial cells Peled et al., 2000
ECM Shimizu et al., 1990
3 Integrin β1α45 (VLA-5) Fibronectin ECM Shimizu et al., 1990
4 Integrin β1α6 (VLA-6) Laminin ECM Shimizu et al., 1990
5 Integrin β1α2 Fibronectin Fibrinogen Vitronectin von Willebrand factor ECM Gekas and Graf, 2013
6 Integrin β1α9 VCAM-1 Endothelial cells Liu et al., 2018
7 Integrin β3α5 MAdCAM Periostin ECM Khurana et al., 2016
8 Integrin β7α4 VCAM-1 Endothelial cells Katayama et al., 2004
9 ESL-1 E-selectin Endothelial cells Leiva et al., 2016
10 PSGL-1 E-selectin Endothelial cells Leiva et al., 2016
P-selectin Endothelial cells Lévesque et al., 1999
11 CD162 P-selectin Endothelial cells Lévesque et al., 1999
12 CD34 L-selectin
13 CD44 Hyaluronic acid MSC ECM Avigdor et al., 2004; Wagner et al., 2008
14 Notch Jagged MSCs Endothelial cells Osteoblasts Osteoclasts Azizidoost et al., 2015
15 N-cadherin N-cadherin MSCs Zhao et al., 2019
16 Eph Ephrin MSCs Foo et al., 2006