TABLE 1.
Sr. no. | Adhesion molecules on HSCs | Receptor molecules in niche | Niche component expressing receptor molecules | References |
1 | Integrin β1αL (LFA-1) | ICAM-1 | Endothelial cells | Shimizu et al., 1990 |
2 | Integrin β1α4 (VLA-4) | VCAM-1/fibronectin | Endothelial cells | Peled et al., 2000 |
ECM | Shimizu et al., 1990 | |||
3 | Integrin β1α45 (VLA-5) | Fibronectin | ECM | Shimizu et al., 1990 |
4 | Integrin β1α6 (VLA-6) | Laminin | ECM | Shimizu et al., 1990 |
5 | Integrin β1α2 | Fibronectin Fibrinogen Vitronectin von Willebrand factor | ECM | Gekas and Graf, 2013 |
6 | Integrin β1α9 | VCAM-1 | Endothelial cells | Liu et al., 2018 |
7 | Integrin β3α5 | MAdCAM Periostin | ECM | Khurana et al., 2016 |
8 | Integrin β7α4 | VCAM-1 | Endothelial cells | Katayama et al., 2004 |
9 | ESL-1 | E-selectin | Endothelial cells | Leiva et al., 2016 |
10 | PSGL-1 | E-selectin | Endothelial cells | Leiva et al., 2016 |
P-selectin | Endothelial cells | Lévesque et al., 1999 | ||
11 | CD162 | P-selectin | Endothelial cells | Lévesque et al., 1999 |
12 | CD34 | L-selectin | ||
13 | CD44 | Hyaluronic acid | MSC ECM | Avigdor et al., 2004; Wagner et al., 2008 |
14 | Notch | Jagged | MSCs Endothelial cells Osteoblasts Osteoclasts | Azizidoost et al., 2015 |
15 | N-cadherin | N-cadherin | MSCs | Zhao et al., 2019 |
16 | Eph | Ephrin | MSCs | Foo et al., 2006 |