Fig. 3.

Regulation of cell cycle progression, cellular division and hypertrophy during regeneration. The progression phase of liver regeneration depends on the synchronized expression of cell cycle genes. Within hepatocytes, cyclins and CDKs, as well as their inhibitors, show a similar expression pattern to that observed in vitro models of cell culture. However, many new functions have been shown recently, such as regulation of DNA replication by CDK1, or interactions with metabolic pathways