Table 3.

Multivariate regression analysis of the effect of serum lymphocyte % on 6-min walking distance and quality of life.

	6 MW distance, m		CAT score		SGRQ score
	Estimated mean (SE)	P value	Estimated mean (SE)	P value	Estimated mean (SE)	P value
Baseline lymphocyte, %
Lymphocyte, %	1.56 (0.45)	0.001	− 0.16 (0.04)	< 0.001	− 0.37 (0.10)	< 0.001
Lymphocyte groups
Normal lymphocytea	Reference		Reference		Reference
Low lymphocyteb	− 32.26 (64.67)	0.618	− 1.37 (6.00)	0.820	− 1.53 (11.15)	0.891
Clustered analysis
Lymphocyte, %	1.88 (0.39)	< 0.001	− 0.16 (0.04)	< 0.001	− 0.42 (0.09)	< 0.001
Lymphocyte groups
Normal lymphocytea	Reference		Reference		Reference
Low lymphocyteb	− 41.31 (8.94)	< 0.001	2.62 (1.05)	0.013	10.10 (2.02)	< 0.001

Adjusted for age, sex, body mass index, smoking status (current or former), and baseline forced expiratory volume in 1 s, % predicted.

SE standard error, 6 MW 6-min walking, CAT COPD assessment test, SGRQ St. George's respiratory questionnaire.

^aNormal lymphocyte group was defined as those with serum lymphocyte percentage 20 to 51%.

^bLow lymphocyte group was defined as those with serum lymphocyte percentage < 20%.