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. 2020 Jul 16;10:11818. doi: 10.1038/s41598-020-68874-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Biodistribution of DIR-labeled BMM in Parkin Q311(X)A mice by IVIS. DIR-labeled BMM were administered in PD mice (12 mo. of age) (A, D) i.v. (4 × 10⁶ cells/200 µL), (B, E) i.p. (4 × 10⁶ cells/200 µL), or (C, F) i.t. (1 × 10⁶ cells/50 µL). Images were recorded (A–C) in live animals at different time points, and (D–F) in main organs, liver (1), spleen (2), kidney (3), lungs (4), and brain (5), collected at the endpoint (72 h). Prone representative images show DIR signal accumulation in the brain for all administration routes examined, especially at 24–72 h. Accumulation of labeled macrophages was also observed in the main peripheral organs.