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. 2020 Jul 16;10:11818. doi: 10.1038/s41598-020-68874-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Biodistribution of ¹⁹F-labeled macrophages in Parkin Q311(X)A mice over time by MRI. ¹⁹F- labeled BMM were injected i.t. into PD mice (12 mo. of age, 1 × 10⁶ cells/50 µL) and 1H/19F fusion image was obtained. Anatomic image is represented in gray scale with cell loading represented by the color. A phantom standard is external to the animal. Representative dual mode brain MR images show significant accumulation of i.t. administered BMM in the brain, especially at 48 h time point.