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. 2020 Jul 16;10:11818. doi: 10.1038/s41598-020-68874-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of BMM administration on the levels of inflammatory signals in mice. Healthy WT mice were injected with saline (white bars), sham BMM (stripped bars), or GDNF-transfected BMM (black bars), and the inflammation signals in the main organs was assessed by the levels of RANTES (A), TNF-a (B), MCP-1 (C), IL-6 (D). No significant increases of inflammatory signals were found in the brain. Some slight increases in RANTES, and MCP-1 were registered in spleen and liver (A, C). TNF-a levels were significantly decreased in spleen upon sham BMM injection. Values are means ± SEM (N = 10). *p < 0.05 compared to saline-injected control mice. Individual data points shown in Supplementary Tables S11–S14.