Figure 8.

Schematic representation of different pathways for adoptively transferred macrophages to the brain. Autologous macrophages transfected with reporter or therapeutic—encoding pDNA were injected via i.v., i.p., or i.t. routes. Different ways of brain entrance across (A) the BBB, or (B): CSF barrier are shown. (A) Macrophages injected through i.v. or i.p. routes cross the BBB and deliver the encoded proteins to the parenchyma. (B) In addition, macrophages injected i.p. may enter the brain through lymphatic system. Macrophages administered through i.t. route mainly enter through the CSF barrier.