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. 2020 Jul 16;11:3570. doi: 10.1038/s41467-020-17312-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Pairwise genetic correlation between human ageing studies. b Genetic correlations of age-stratified parental lifespan against healthspan and longevity. c Genetic correlations (r_g) of ageing traits with traits related to development, behaviour, and disease. In bold are traits with heterogeneous correlations (P_het < 0.05). Displayed here are 17 traits which have at least one significant (FDR < 5%) genetic correlation with healthspan, parental lifespan, or longevity, out of the 27 traits tested. The 17 traits are clustered by Euclidean distance based on their genetic correlation with all tested traits (30 in total). See Supplementary Data 1 for a full list of correlations and Supplementary Table 1 for the number of SNPs used to calculate each pairwise correlation. Blank squares represent correlations which did not pass multiple testing correction. Note that fewer correlations with longevity will pass this threshold due to the smaller sample size of this GWAS. Error bars represent 95% confidence intervals of the correlation estimates. COPD: chronic obstructive pulmonary disease.