Table 1.
Ten loci act across all three ageing traits, reaching nominal significance in each dataset.
| Nearest Gene | rsID | A1 | Freq1 | βhealthspan | Phealthspan | βlifespan | Plifespan | βlongevity | Plongevity | PMANOVA |
|---|---|---|---|---|---|---|---|---|---|---|
| SLC4A7 | rs2643826 | C | 0.55 | 0.021 (0.005) | 2E−05 | 0.017 (0.004) | 2E−05 | 0.045 (0.020) | 3E−02 | 4E−08 |
| LINC02513 | rs17499404 | A | 0.54 | 0.017 (0.005) | 7E−04 | 0.012 (0.004) | 2E−03 | 0.084 (0.019) | 1E−05 | 4E−08 |
| FOXO3 | rs1159806 | T | 0.35 | 0.014 (0.005) | 5E−03 | 0.015 (0.004) | 2E−04 | 0.095 (0.020) | 3E−06 | 1E−08 |
| ZW10 | rs61905747 | A | 0.82 | 0.029 (0.006) | 2E−06 | 0.024 (0.005) | 2E−06 | 0.066 (0.026) | 1E−02 | 4E−10 |
| FGD6 | rs12830425 | G | 0.07 | 0.044 (0.009) | 3E−06 | 0.032 (0.007) | 2E−05 | 0.077 (0.036) | 3E−02 | 8E−09 |
| LPA | rs10455872 | A | 0.93 | 0.057 (0.009) | 1E−10 | 0.076 (0.007) | 9E−25 | 0.124 (0.045) | 7E−03 | 4E−30 |
| CDKN2B-AS1 | rs7859727 | C | 0.51 | 0.031 (0.005) | 3E−10 | 0.025 (0.004) | 1E−10 | 0.066 (0.019) | 6E−04 | 4E−18 |
| TOX3 | rs4783780 | A | 0.53 | 0.023 (0.005) | 2E−06 | 0.014 (0.004) | 3E−04 | 0.052 (0.019) | 6E−03 | 1E−08 |
| LDLR | rs6511720 | T | 0.12 | 0.015 (0.007) | 4E−02 | 0.034 (0.006) | 2E−08 | 0.093 (0.030) | 2E−03 | 4E−09 |
| APOE | rs429358 | T | 0.85 | 0.014 (0.007) | 4E−02 | 0.106 (0.005) | 3E−83 | 0.510 (0.032) | 1E−56 | 1E−126 |
β effect size of the A1 allele with the standard error in parentheses.
For healthspan and parental lifespan units are the negative log of the hazard ratio, for longevity this is the log odds of reaching an exceptional old age (90th percentile).
In bold are loci which contain SNPs that are not reported at genome-wide significance in any individual dataset. The remaining loci contain one or more genome-wide significant SNPs within 500 kb of the lead SNP in one of the individual datasets (Supplementary Data 4).
Nearest gene: gene closest to the index SNP, rsID the SNP with the lowest P value in the multivariate analysis, A1 the effect allele, increasing healthspan, parental lifespan, and odds to become long-lived, Freq1 frequency of the A1 allele. P P value of the trait association. For MANOVA, this is the P value against the null hypothesis of association with neither healthspan, parental lifespan, nor longevity.