Table 2.
eQTL for 78 genes colocalise with the GWAS signal at 9 out of 10 loci of interest.
| Locus | Chr | Position | Cis-genes | Trans-genes |
|---|---|---|---|---|
| SLC4A7 | 3 | 27562988 | NEK10− | |
| LINC02513 | 4 | 38385479 | EDAR+, MAL+, NOSIP+, CCR7+, ABLIM1+, KRT72+, FHIT+, MMP28+, EPHX2+, LEF1+ | |
| FOXO3 | 6 | 109006838 | LINC00222−, FOXO3− | FOXO3B+, MEGF6+, CALCOCO1+, CYBRD1+, IGF1R+, PHF21A+, NDRG1+, KIAA1324−, FCHO2+, CNNM3+ |
| LPA | 6 | 161010118 | SLC22A1+, SLC22A3−, AL591069.1−, MAP3K4− | |
| CDKN2B-AS1 | 9 | 22102165 | CDKN2B+ | |
| ZW10 | 11 | 113639842 | USP28+, ANKK1+, TTC12−, RP11−159N11.4−, ANKK1− | |
| FGD6 | 12 | 95580818 | RP11−256L6.3+, FGD6− | |
| LDLR | 19 | 11202306 | CTC−510F12.2+, KANK2+, SPC24+, SLC44A2+, ILF3+, ILF3−AS1−, DOCK6−, SMARCA4−, PDE4A+ | AHSP−, SELENBP1−, EPB42−, SLC4A1−, HBD−, CA1−, FAM46C−, BLVRB−, TMOD1−, GYPB−, UBE2O−, BPGM−, TRIM58−, SNCA−, IFIT1B−, FECH−, GMPR−, EPB49−, RBM38−, TNS1−, MICAL2−, DCAF12−, RAB3IL1−, PDZK1IP1−, HBM−, BCL2L1−, PLEK2−, E2F2−, TGM2− |
| APOE | 19 | 45411941 | EXOC3L2−, AC006126.4+, CKM+, BCL3+, PVRL2+ | LDLR− |
Genes which showed a significant effect (FDR < 5%) of gene expression on ageing traits are displayed here.
Gene names are annotated with the direction of effect, where + and – indicate whether the life-extending association of the locus is linked with higher or lower gene expression, respectively.
Locus: nearest gene to lead variant in the multivariate analysis, Chr: chromosome, Position: base-pair position of lead variant (GRCh37), Cis-genes: genes in physical proximity (<500 kb) to the lead variant of the locus which colocalise with the multivariate signal, Trans-genes: genes located more than 500 kb from the lead variant of the locus.