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. 2020 Jul 16;10:11802. doi: 10.1038/s41598-020-67877-8

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2022

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Power simulation in three scenarios. The power (%) of our model to detect significant interactions depending on the initial parameters are shown. Three sets of estimated initial parameters corresponding to the model estimates from the pairs of RH5/AMA1-RON2L (a), CyRPA/RIPR (b), and RH5/RH4 (c, *data from Williams et al.²⁶). (a) has an interaction effect of close to zero, ( $τ_{1} =$ − 0.06), (b) has a modest synergy effect ( $τ_{1} =$ 0.25), and (c) has a large synergy effect ( $τ_{1} =$ 36). The x-axis is the number of concentrations for one of the antibodies tested in an assay. For example, grid of 3 means each antibody is tested at 3 different concentrations, totaling 3 × 3 = 9 conditions per assay. The y-axis is the number of times to repeat the assay.