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. 2020 Jul 16;10:11693. doi: 10.1038/s41598-020-68086-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Quantification of the abundance of markers of interest on Iba1-positive cells. Iba1-positive cells were manually counted in the human middle temporal gyrus and the proportion immunoreactive for MOIs P2RY12, TMEM119, HLA-DR, CD74, CD206, CD32, CD163, or L-Ferritin was determined. The number of MOI-positive cells were normalized to the total number of Iba1-positive cells, and the percentages of MOI-positive cells in GM and WM were compared using paired t-tests. Data presented with each case represented by a single point and the percentages measured in GM and WM are joined per case (n = 6). Significant difference between GM and WM: *p < 0.05.