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. 2020 Jul 16;11:3563. doi: 10.1038/s41467-020-17387-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Heatmap with hierarchical clustering illustrating changes in the abundance of cellular phosphopeptides across the different cancer-related Dyrk2 point mutants. Only those peptides that have been detected at least once as statistically significantly changed (adj. p-value ≤ 0.01, │log2FC│ > 0.5) are displayed. b Content of regulated proteins and phosphopeptides summarized from all Dyrk2-mutant cell lines (regulated phosphopeptides:│log2FC│ > 1, adj. p-value ≤ 0.05). c Fraction of significantly upregulated or downregulated localized phosphopeptides in cell lines expressing the Dyrk2 point mutants (│log2FC│ > 1, adj. p-value ≤ 0.05). d Phosphomotif analysis of downregulated phosphopeptides in the different Dyrk2 variants (adj. p-value ≤ 0.05) (left panel). Fraction of downregulated phosphopeptides containing the Dyrk2 phosphomotif (right panel). The statistical analysis and p-value calculation (adj. p-value (FDR)) was performed within the mapDIA package⁶⁰. Source data are provided as source data file.