Table 2.
Mean foveal avascular zone (FAZ), vascular branching points and vascular density in the superficial (SCP) and deep (DCP) capillary plexi in the sickle cell disease groups (heterozygous- SC, and homozygous-SS) and control group.
| Group n = number of eyes |
HbSS n = 27 |
HbSC n = 19 |
Control n = 16 |
HbSS vs control p | HbSC vs control p | HbSC vs HbSS p |
|---|---|---|---|---|---|---|
| Mean superficial FAZ ± SD (range) mm2 | 0.44 ± 0.16 (0.1–0.7) | 0.48 ± 0.12 (0.3–0.7) | 0.42 ± 0.09 (0.2–0.5) | 0.85 | 0.25 | 0.49 |
| Mean deep FAZ ± SD (range) mm2 | 0.84 ± 0.3 (0.3–1.5) | 0.86 ± 0.28 (0.5–1.5) | 0.57 ± 0.09 (0.4–0.8) | 0.0004 | 0.0001 | 0.98 |
| Vascular branching points in the SCP (n/mm2) | 92 ± 21 (49–126) | 101 ± 17 (73–131) | 98 ± 17 (76–127) | 0.29 | 0.55 | 0.15 |
| Vascular branching points in the DCP (n/mm2) | 27.9 ± 5.6 (17–38) | 29.9 ± 6.8 (17–41) | 37.3 ± 9.4 (27–55) | 0.0014 | 0.034 | 0.3 |
| Vascular density in the SCP | 0.79 ± 0.01 (0.8–0.9) | 0.85 ± 0.01 (0.81–0.87) | 0.85 ± 0.01 (0.81–0.89) | 0.01 | 0.38 | 0.01 |
| Vascular density in the DCP | 0.25 ± 0.02 (0.22–0.3) | 0.26 ± 0.01 (0.2–0.29) | 0.29 ± 0.02 (0.2–0.35) | 0.0001 | 0.001 | 0.4 |
Bold characters indicate that p-value is significant.