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. 2020 Jul 16;10:11754. doi: 10.1038/s41598-020-68254-1

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Corneal model for measuring penetration. (A) Illustrative diagram of the location from which 5 mm discs were cut from the cornea. (B) Illustrative diagram showing a 5 mm porcine corneal disc fitted between plastic 96 well plate inserts. The combined insert is placed into a well containing Hanks’ Balanced Salt Solution (HBSS). Solution containing the compound of interest is then applied to the upper, epithelial, surface shown in yellow. (C) Photograph of inserts showing inner insert and outer inserts separately. The disc of corneal tissue is placed in the base of the outer insert and the inner insert placed on top to sandwich it against the base before placing the combined inserts into the 96 well plate.