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. 2020 Jul 16;10:11788. doi: 10.1038/s41598-020-68585-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The morphological change of the physically-based CAP-treated hTERT/E6/E7 cells. For the control group, the medium was also renewed. No CAP treatment was performed before imaging. The photos were taken at 11 min after the CAP treatment. The clear bubbles on the cellular membrane were marked by yellow arrows. 2 mL of hTERT/E6/E7 cells (3 × 10⁴ cell/mL) were seeded in 35 mm dishes and cultured for 48 h in the incubator. The scale bar was 100 μm (black). All photos were taken by using a Nikon TS100 inverted phase-contrast microscope.