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. 2020 Jul 16;10:11800. doi: 10.1038/s41598-020-67037-y

Table 2.

Study quality and risk of bias assessment of included studies on oral probiotic intake according to the Cochrane Collaboration’s tool.

Study (year) Random sequence generation Allocation concealment Blinding of participants and personnel Blinding of outcome assessment Incomplete outcome data Selective outcome reporting Other sources of bias Overall quality*
Harbige et al. (2016) U U U U L L H Poor
Childs et al. (2014) L L L L L L U Good
Rizzardini et al. (2012) L L L U L L L Good
Cox et al. (2008) U L L U L L L Fair
Kekkonen et al. (2008) U U U U L L L Poor

U; unclear risk of bias, L; low risk of bias, H; high risk of bias.

*Good quality: all criteria met; Fair quality: one criterion not met (i.e. high risk of bias for one domain or two criteria unclear); Poor quality: two or more criteria listed as high or unclear risk of bias.