Fig. 6.

ORCA‐010 counteracts melanoma‐mediated inhibition of the release of type‐1 effector cytokines by monocyte‐derived dendritic cells (moDCs). Day 6 supernatants from the mixed lymphocyte reactions from three independent experiments were collected and cytokines measured. (a) interferon (IFN)‐γ, (b) interleukin (IL)‐2, (c) tumor necrosis factor (TNF)‐α and (d) IL‐10 levels secreted by T cells under the different conditions. Data shown are means ± standard error of the mean (s.e.m.). Statistical significances between cultures with or without oncolytic virus were tested using a matched repeated‐measures one‐way analysis of variance (anova) with Fisher’s least significant difference (LSD) post‐hoc test. *P < 0·05 and **P < 0·01.