Table 1.
IEDB inventory of coronavirus B and T cell epitopes
A) | |||||||
---|---|---|---|---|---|---|---|
Coronavirus |
|||||||
Alpha | Beta |
Gamma | |||||
Epitope set | Type | SARS-CoV | MERS-CoV | Other | Total | ||
B cell | Conformational | 18 | 27 | 23 | 2 | 11 | 81 |
Linear | 81 | 405 | 5 | 60 | 30 | 581 | |
T cell | 61 | 164 | 25 | 54 | 16 | 320 | |
B) | |||||||
Coronavirusb |
|||||||
Alpha | Beta |
Gamma | |||||
Epitope set | Host | SARS-CoV | MERS-CoV | Other | Total | ||
B cella | Humans | 0 | 306 | 16 | 0 | 0 | 322 |
Mice | 62 | 154 | 9 | 58 | 20 | 303 | |
Other | 42 | 142 | 5 | 6 | 23 | 218 | |
Tg mice | 0 | 0 | 0 | 0 | 0 | 0 | |
T cell | Humans | 2 | 92 | 0 | 1 | 0 | 95 |
Mice | 16 | 99 | 25 | 53 | 1 | 194 | |
Other | 46 | 1 | 0 | 0 | 15 | 62 | |
Tg mice | 0 | 29 | 0 | 0 | 0 | 29 |
C) | |||||||
---|---|---|---|---|---|---|---|
SARS protein | Bcell | T cell | |||||
Spike glycoprotein | 279 | 48 | |||||
Nucleoprotein | 113 | 33 | |||||
Membrane protein | 20 | 4 | |||||
Replicase polyprotein lab | 8 | 9 | |||||
Protein 3a | 2 | 7 | |||||
Envelope small membrane protein | 2 | 0 | |||||
Non-structural protein 3b | 2 | 0 | |||||
Protein 7a | 2 | 0 | |||||
Protein 9b | 2 | 0 | |||||
Non-structural protein 6 | 1 | 0 | |||||
Protein non-structural 8a | 1 | 0 |
B cell includes both conformational and linear epitipes.
Totals between A) and B) may not be equal as several epitopes are recognized in multiple species.
T cell epitope total includes epitopes recognized in humans and/or transgenic mice.