Table 3.

Differentially expressed genes in BALF of COVID-19 patients that are known to be regulated by MNK - eIF4E signaling based on studies in eIF4ES209A-knock-in mutant cells and animals. These knock-in animals and cells are null mutants for eIF4E phosphorylation.

Gene Symbol	Gene Name	COVID19 BALF	eIF4ES209A-KI vs. WT	References
Downregulated
CCL2	C-C motif chemokine ligand 2	↑	↓	(Furic et al., 2010; Huang et al., 2020a; Liao et al., 2020; Xiong et al., 2020b)
CCL7	C-C motif chemokine ligand 7	↑	↓	(Furic et al., 2010; Liao et al., 2020; Xiong et al., 2020b)
CD14	Cluster of differentiation 14	↑	↓	(Amorim et al., 2018; Liao et al., 2020)
CYP1B1	Cytochrome P450 1B1	↑	↓	(Furic et al., 2010; Liao et al., 2020)
NCF1	Neutrophil cytosolic factor 1	↑	↓	(Amorim et al., 2018; Liao et al., 2020)
NFKBIA	NFKB inhibitor alpha	↑	↓	(Furic et al., 2010; Liao et al., 2020)
S100A9	S100 calcium-binding protein A9	↑	↓	(Amorim et al., 2018; Liao et al., 2020)
VEGFA	Vascular endothelial growth factor A	↑	↓	(Amorim et al., 2018; Xiong et al., 2020a)
Upregulated
TNF	Tumor necrosis factor	↑	↑	(Aguilar-Valles et al., 2018; Huang et al., 2020a)