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. Author manuscript; available in PMC: 2021 May 1.

Published in final edited form as: Eur J Med Chem. 2020 Mar 13;193:112206. doi: 10.1016/j.ejmech.2020.112206

Table 2.

Effect of the α-alkylthio substituent on the mEH inhibitory potency of 2-cyclopentyl-acetamides.


#	R1	IC₅₀, nM	#	R1	IC₅₀, nM

33	H	7650	49		2100
34		1466	50		315
35		493	51		32
36		1100	52		384
37		500	53		441
38		33	54		399
39		4940	55		773
40		2900	56		26
41		6600	57		11
42		839	58		9
43		422	59		18
44		433	60		10
45		6960	61		10.1
46		899	62		2.2
47		600	63		4.7
48		193	64		14