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Effect of N-substitution on the mEH inhibition by primary amides.
| # | Structure | IC50,μM | Inhibition at 100 μM, % |
|---|---|---|---|
| 65 |  |
12.9 | 83 |
| 66 |  |
15.1 | 80 |
| 67 |  |
61.3 | 67 |
| 68 |  |
> 100 | 5 |
| 69 |  |
> 100,100a | 0,50a |
| 70 |  |
> 100 | 40, 25a |
| 71 |  |
14.7, 12.5a | 65, 98a |
| 72 |  |
> 100 | 33,0 a,b |
| 73 |  |
> 100 | - b |
| 74 |  |
> 100 | - b |
| 75 |  |
> 100 | - b |
| 76 |  |
> 100 | -15 b |
Reaction mixture value.
increase in mEH activity.
