Table 4.
Inhibition data for the compounds that showed more than 10% inhibition of mEH but less than 50% at 50 pM concentration. Blanc reactions did not inhibit mEH.
# | Structure | Inhibition at 50 (μM,% | # | Structure | Inhibition at 50 μM,% |
---|---|---|---|---|---|
77 | ![]() |
60a | 108 | ![]() |
15 |
78 | ![]() |
25 | 109 | ![]() |
12 |
79 | ![]() |
30 | 110 | ![]() |
33 |
80 | ![]() |
40 | 111 | ![]() |
18 |
81 | ![]() |
40 | 112 | ![]() |
15 |
82 | ![]() |
38 | 113 | ![]() |
22 |
83 | ![]() |
30 | 114 | ![]() |
12 |
84 | ![]() |
15 | 115 | ![]() |
29 |
85 | ![]() |
20 | 116 | ![]() |
17 |
86 | ![]() |
45 | 117 | ![]() |
45 |
87 | ![]() |
20 | 118 | ![]() |
24 |
88 | ![]() |
20 | 119 | ![]() |
10 |
89 | ![]() |
20 | 120 | ![]() |
31 |
90 | ![]() |
25 | 121 | ![]() |
23 |
91 | ![]() |
24 | 122 | ![]() |
11 |
92 | ![]() |
15 | 123 | ![]() |
36 |
93 | ![]() |
41 | 124 | ![]() |
41 |
94 | ![]() |
31 | 125 | ![]() |
38 |
95 | ![]() |
26 | 126 | ![]() |
19 |
96 | ![]() |
32 | 128 | ![]() |
19 |
97 | ![]() |
32 | 128 | ![]() |
19 |
98 | ![]() |
20 | 129 | ![]() |
37 |
99 | ![]() |
31 | 130 | ![]() |
36 |
100 | ![]() |
25 | 131 | ![]() |
34 |
101 | ![]() |
18 | 132 | ![]() |
35 |
102 | ![]() |
25 | 133 | ![]() |
37 |
103 | ![]() |
15 | 134 | ![]() |
IC50 = 87 μM b |
104 | ![]() |
11 | 135 | ![]() |
IC50 = 55 μM b |
105 | ![]() |
15 | 136 | ![]() |
IC50 = 96 μM b |
106 | ![]() |
17 | 137 | ![]() |
IC50 = 3.3 μM b |
107 | ![]() |
16 | 138 | ![]() |
IC50 = 1.9 μM |
IC50 = 33.6 μM.
apparent increase in mEH activity at low concentrations.