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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Eur J Med Chem. 2020 Mar 13;193:112206. doi: 10.1016/j.ejmech.2020.112206

Table 4.

Inhibition data for the compounds that showed more than 10% inhibition of mEH but less than 50% at 50 pM concentration. Blanc reactions did not inhibit mEH.

# Structure Inhibition at 50 (μM,% # Structure Inhibition at 50 μM,%

77 graphic file with name nihms-1578625-t0082.jpg 60a 108 graphic file with name nihms-1578625-t0083.jpg 15
78 graphic file with name nihms-1578625-t0084.jpg 25 109 graphic file with name nihms-1578625-t0085.jpg 12
79 graphic file with name nihms-1578625-t0086.jpg 30 110 graphic file with name nihms-1578625-t0087.jpg 33
80 graphic file with name nihms-1578625-t0088.jpg 40 111 graphic file with name nihms-1578625-t0089.jpg 18
81 graphic file with name nihms-1578625-t0090.jpg 40 112 graphic file with name nihms-1578625-t0091.jpg 15
82 graphic file with name nihms-1578625-t0092.jpg 38 113 graphic file with name nihms-1578625-t0093.jpg 22
83 graphic file with name nihms-1578625-t0094.jpg 30 114 graphic file with name nihms-1578625-t0095.jpg 12
84 graphic file with name nihms-1578625-t0096.jpg 15 115 graphic file with name nihms-1578625-t0097.jpg 29
85 graphic file with name nihms-1578625-t0098.jpg 20 116 graphic file with name nihms-1578625-t0099.jpg 17
86 graphic file with name nihms-1578625-t0100.jpg 45 117 graphic file with name nihms-1578625-t0101.jpg 45
87 graphic file with name nihms-1578625-t0102.jpg 20 118 graphic file with name nihms-1578625-t0103.jpg 24
88 graphic file with name nihms-1578625-t0104.jpg 20 119 graphic file with name nihms-1578625-t0105.jpg 10
89 graphic file with name nihms-1578625-t0106.jpg 20 120 graphic file with name nihms-1578625-t0107.jpg 31
90 graphic file with name nihms-1578625-t0108.jpg 25 121 graphic file with name nihms-1578625-t0109.jpg 23
91 graphic file with name nihms-1578625-t0110.jpg 24 122 graphic file with name nihms-1578625-t0111.jpg 11
92 graphic file with name nihms-1578625-t0112.jpg 15 123 graphic file with name nihms-1578625-t0113.jpg 36
93 graphic file with name nihms-1578625-t0114.jpg 41 124 graphic file with name nihms-1578625-t0115.jpg 41
94 graphic file with name nihms-1578625-t0116.jpg 31 125 graphic file with name nihms-1578625-t0117.jpg 38
95 graphic file with name nihms-1578625-t0118.jpg 26 126 graphic file with name nihms-1578625-t0119.jpg 19
96 graphic file with name nihms-1578625-t0120.jpg 32 128 graphic file with name nihms-1578625-t0121.jpg 19
97 graphic file with name nihms-1578625-t0122.jpg 32 128 graphic file with name nihms-1578625-t0123.jpg 19
98 graphic file with name nihms-1578625-t0124.jpg 20 129 graphic file with name nihms-1578625-t0125.jpg 37
99 graphic file with name nihms-1578625-t0126.jpg 31 130 graphic file with name nihms-1578625-t0127.jpg 36
100 graphic file with name nihms-1578625-t0128.jpg 25 131 graphic file with name nihms-1578625-t0129.jpg 34
101 graphic file with name nihms-1578625-t0130.jpg 18 132 graphic file with name nihms-1578625-t0131.jpg 35
102 graphic file with name nihms-1578625-t0132.jpg 25 133 graphic file with name nihms-1578625-t0133.jpg 37
103 graphic file with name nihms-1578625-t0134.jpg 15 134 graphic file with name nihms-1578625-t0135.jpg IC50 = 87 μM b
104 graphic file with name nihms-1578625-t0136.jpg 11 135 graphic file with name nihms-1578625-t0137.jpg IC50 = 55 μM b
105 graphic file with name nihms-1578625-t0138.jpg 15 136 graphic file with name nihms-1578625-t0139.jpg IC50 = 96 μM b
106 graphic file with name nihms-1578625-t0140.jpg 17 137 graphic file with name nihms-1578625-t0141.jpg IC50 = 3.3 μM b
107 graphic file with name nihms-1578625-t0142.jpg 16 138 graphic file with name nihms-1578625-t0143.jpg IC50 = 1.9 μM
a

IC50 = 33.6 μM.

b

apparent increase in mEH activity at low concentrations.