Table 4.
Inhibition data for the compounds that showed more than 10% inhibition of mEH but less than 50% at 50 pM concentration. Blanc reactions did not inhibit mEH.
| # | Structure | Inhibition at 50 (μM,% | # | Structure | Inhibition at 50 μM,% |
|---|---|---|---|---|---|
| 77 | ![]() |
60a | 108 | ![]() |
15 |
| 78 | 25 | 109 | ![]() |
12 | |
| 79 | 30 | 110 | ![]() |
33 | |
| 80 | ![]() |
40 | 111 | ![]() |
18 |
| 81 | ![]() |
40 | 112 | ![]() |
15 |
| 82 | 38 | 113 | ![]() |
22 | |
| 83 | ![]() |
30 | 114 | ![]() |
12 |
| 84 | ![]() |
15 | 115 | ![]() |
29 |
| 85 | ![]() |
20 | 116 | ![]() |
17 |
| 86 | ![]() |
45 | 117 | ![]() |
45 |
| 87 | ![]() |
20 | 118 | ![]() |
24 |
| 88 | ![]() |
20 | 119 | ![]() |
10 |
| 89 | ![]() |
20 | 120 | ![]() |
31 |
| 90 | ![]() |
25 | 121 | ![]() |
23 |
| 91 | ![]() |
24 | 122 | ![]() |
11 |
| 92 | 15 | 123 | ![]() |
36 | |
| 93 | ![]() |
41 | 124 | ![]() |
41 |
| 94 | ![]() |
31 | 125 | ![]() |
38 |
| 95 | ![]() |
26 | 126 | ![]() |
19 |
| 96 | ![]() |
32 | 128 | ![]() |
19 |
| 97 | ![]() |
32 | 128 | ![]() |
19 |
| 98 | ![]() |
20 | 129 | ![]() |
37 |
| 99 | ![]() |
31 | 130 | ![]() |
36 |
| 100 | ![]() |
25 | 131 | ![]() |
34 |
| 101 | ![]() |
18 | 132 | ![]() |
35 |
| 102 | ![]() |
25 | 133 | ![]() |
37 |
| 103 | ![]() |
15 | 134 | ![]() |
IC50 = 87 μM b |
| 104 | ![]() |
11 | 135 | ![]() |
IC50 = 55 μM b |
| 105 | ![]() |
15 | 136 | ![]() |
IC50 = 96 μM b |
| 106 | ![]() |
17 | 137 | ![]() |
IC50 = 3.3 μM b |
| 107 | ![]() |
16 | 138 | ![]() |
IC50 = 1.9 μM |
IC50 = 33.6 μM.
apparent increase in mEH activity at low concentrations.

























































