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. 2020 Jul 10;11:1073. doi: 10.3389/fphar.2020.01073

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Copyright © 2020 Zhang, Peng, Zhang, Dong, Wang, Liu, Xia and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of ex527 treatment on SIRT1/HMGB1/TLR4/Myd88/Nf-κB signaling pathway after SAH. (A–F) Western blot assay (A) and quantification for the expression of SIRT1 (B), HMGB1 (C), TLR4 (D), Myd88 (E), and Nf-κB p65 (F) in the indicated groups. n = 6 per group. (G–J) Quantification of IL-1β (G), IL-6 (H), TNF-α (I) and ICAM-1 (J) protein expressions in all groups. n = 6 per group. (K) Representative photomicrographs of immunofluorescence staining for Iba-1. (L) Quantitative analysis of the Iba-1 immunofluorescence staining. n = 6 per group. Bars represent the mean ± SD. ^* P < 0.05.