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. 2020 Jul 10;10:1108. doi: 10.3389/fonc.2020.01108

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Copyright © 2020 Li, Li, Li, Shen, Zhang, Bi and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MNX1-AS1 promotes progression of TNBC in vitro. (A) MNX1-AS1 mainly expressed in cytoplasm in MDA-MB-231, as indicated by Immunofluorescence. (B) Silencing efficacy of siRNAs (si-1 and si-2) to MNX1-AS1 were over 50% in MDA-MB-231. MNX1-AS1 expression was determined using qRT-PCR and normalized to siCTL expression. Bar graphs represent the mean ± SD of experimental triplicates. (C) Silencing MNX1-AS1 reduced viability of MDA-MB-231, as detected by MTS assay. Bar graphs represent the mean ± SD of experimental triplicates. (D) Silencing MNX1-AS1 reduced colony formation of MDA-MB-231. (E,F) Silencing MNX1-AS1 reduced migration and invasion of MDA-MB-231 cells. Culture inserts were coated with or without matrigel for the Boyden chamber assay of MDA-MB-231. (G) Silencing MNX1-AS1 induced apoptosis of MDA-MB231 cells. **P < 0.01 and ***P < 0.001.