Table 1.
Background levels of 1,2-NPQ- and 1,4-NPQ-derived Alb adducts in human serum derived from women with breast cancer and healthy controls.
| Adducts | Patients (n = 143) | Healthy controls (n = 119) |
|---|---|---|
| 1,2-NPQ-Alb (pmole/g-Alb) | ||
| Mean (SD) | 210 (130)a | 113 (51.9) |
| Median | 178 | 102 |
| Range | NDb–674 | 28.3–263 |
| 1,4-NPQ-Alb (pmole/g-Alb) | ||
| Mean (SD) | 73.7 (52.3) | 174 (108)a |
| Median | 58.8 | 144 |
| Range | NDb–397 | 46.2–674 |
| Ratio of mean levels of 1,2-NPQ-Alb to 1,4-NPQ-Alb | 2.85 (2.49)b | 0.650 (0.480) |
a, Statistical significance, p < 0.001. b, Not detected. The limit of detection corresponds to 10 pmol/g for all adducts, assuming 10 mg protein was used for the assay.