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. 2020 Jul 16;10:11824. doi: 10.1038/s41598-020-68796-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Representative metabolic pathway maps of significantly altered metabolites during proliferation and differentiation. Key metabolites related to (A) Pantothenate and CoA biosynthesis and Arginine and Proline metabolism that display significant alteration during proliferation and (B) Glutathione metabolism, (C) Tryptophan metabolism during differentiation. Colored boxes represent identified metabolites. Images were modified from map00770 and map00220 respectively for (A), map00480 for (B), and map00380 for (C) from the KEGG database (https://www.kegg.jp).

Representative metabolic pathway maps of significantly altered metabolites during proliferation and differentiation. Key metabolites related to (A) Pantothenate and CoA biosynthesis and Arginine and Proline metabolism that display significant alteration during proliferation and (B) Glutathione metabolism, (C) Tryptophan metabolism during differentiation. Colored boxes represent identified metabolites. Images were modified from map00770 and map00220 respectively for (A), map00480 for (B), and map00380 for (C) from the KEGG database (https://www.kegg.jp).