Table 1.
Characteristics of Variants and Mutants
| Group A | Group B | Group C | |
|---|---|---|---|
| Number of variants or mutants | 29 | 51 | 26 |
| Increased infectivity | D614G, D614G+L5F, D614G+D936Y, D614G+S939F, D614G+S943T | D614G+V341I, D614G+K458R, D614G+I472Va | none |
| Decreased infectivity | Q239K, D839Y, P1263L, D614G+Q675H | V341I, D364Y, 385-387del, D405V, Q414P, I434K, S438F, D467V, P491R, V503F, R509K, V510L, P521S | N122Q, N343Q, N717Q, T719A, N801Q, N1074Q, N331Q+N343Q |
| Increased sensitivity to neutralizing mAbs | none | V367F, Q409E, Q414E, I468F, I468T, Y508H, A522V | N165Q, N709Q |
| Decreased sensitivity to neutralizing mAbs | A831V | N439K, L452R, A475V, V483A, F490L, Y508H, D614G+A435S, D614G+I472Va | N234Q |
| Increased sensitivity to convalescent sera | V615L | F338L, V367F, I468F, I468T | N149H, N149Q, N165Q, N331Q, N354D, N709Q, N1173Q |
| Decreased sensitivity to convalescent sera | Y145del, A831V, D614G+A831V, D614G+A879S, D614G+M1237I | Q414E, N439K, G446V, K458N, I472V, A475V, T478I, V483I, F490L, H519P, D614G+Q321L, D614G+I472Va | none |
a
D614G+I472V is the only variant with increased infectivity and decreased sensitivity to neutralizing mAb and convalescent sera. It is of note only one sequence is recorded in GISAID.