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. 2020 Jul 17;56(3):106101. doi: 10.1016/j.ijantimicag.2020.106101

Figure 3.

Figure 3

Proposed sites of action of hydroxychloroquine in SARS-CoV-2 infection. The flow diagram shows stages of SARS-CoV-2 infection in the human host and subsequent mechanism of effects leading to target organ damage. The possible sites where HCQ may act are shown by the red arrows. Abbreviations: HCQ, hydroxychloroquine; ARDS, acute respiratory distress syndrome; ACE2 Angiotensin-converting enzyme 2; pp1a & pp1ab polyprotein 1a & polyprotein 1ab; nsp non-structural protein; RAS Renin-angiotensin system.