Table 1.

Summary of known antiviral activity of EGCG.

Virus	Genome	Conclusion	Reference
Porcine reproductive and respiratory syndrome virus (PRRSV)	ssRNA	EGCG effectively inhibits PRRSV infection and replication in porcine alveolar macrophages. It prevents MARC-145 cells from getting infected from PRRSV	Ge et al. (2018)
Hepatitis C virus (HCV)	ssRNA	EGCG prevents infection by inhibiting the entry of HCV into hepatoma cell lines and primary human hepatocytes thus	Ciesek et al. (2011)
Human immunodeficiency virus (HIV)	ssRNA	EGCG interferes with the interaction of host cell receptors and virus envelope and inhibits the entry of the virus into target cells	Liu et al. (2005)
Zika virus	ssRNA	Cells pre-treated with EGCG showed no virus infection	Carneiro et al. (2016)
Chikungunya	ssRNA	The entry, replication, and release were inhibited of CHIKV in vitro by EGCG	Lu et al. (2017)
West Nile Virus (WNV)	ssRNA	EGCG has a direct effect on the WNV when treated at early stages of the infection	Carneiro et al. (2016)
Dengue	ssRNA	EGCG directly interacts with the virus molecule causing virus deformation and thus preventing the virus from infecting further cells	Raekiansyah et al. (2018)
Influenza A/H1N1, A/H3N2, B	ssRNA	EGCG inhibits acidification of intracellular endosome compartments essential in the fusion of membranes of virus and host cell	Song et al. (2005)
Rotavirus	ssRNA	EGCG reduces the reactive oxygen species produced and prevents infection	Ho et al. (2009)
Ebola	ssRNA	EGCG inhibits HSPS5 protein of the host which is the target of Ebola virus treatments thus reducing the virus multiplication once infected	Reid et al. (2014)
Murine norovirus and feline calicivirus	ssRNA	EGCG at 100 μM was found out to be the most potent prophylactic agent when compared with other flavonoids	Seo et al. (2016)