Table 1.

NAFLD-associated HCC epidemiology and burden

Country	Incidence and prevalence	Population	Study period	Ref.
United States	0.21 per 1000 person-years	Veterans Affairs	2003-2011	Kanwal et al.[22]
	14.1% of all cases	SEER registries	2004-2009	Younossi et al.[136]
	8% of all HCC cases	Veterans Affairs	2005-2011	Mittal et al.[23]
	1.56% of HCC cases	Veterans Affairs	2012-2018	Ioannou et al.[24]
	5.29 per 1000 person-years	Meta-analysis	1989-2015	Younossi et al.[3]
	13.5% of all liver transplants	United Network Organ for Sharing	2000-2012	Wong et al.[26]
Spain, Italy, the Netherlands, United Kingdom	0.3 per 1000 person-years	European primary care databases	2016	Alexander et al.[30]
United Kingdom	35% of all HCC referrals	National Health Services	2010	Dyson et al.[137]
Japan	6% incidence	Single hospital in Tokyo	1994-2007	Arase et al.[138]
South Korea	12.2% incidence	South Korean hospital	2006-2010	Cho et al.[34]

NAFLD: nonalcoholic fatty liver disease; HCC: hepatocellular carcinoma; SEER: surveillance, epidemiology and end results