Table 4.
Multivariate Cox regression analysis for need of RRT and mortality
| Variables | HR (95% CI) | P-value |
|---|---|---|
| Need of renal replacement therapy | ||
|
| ||
| Model 1: Age, sex, ischaemic heart disease, peripheral vascular disease, DR, creatinine, proteinuria, treatment with RAASB and DN | ||
| Age, years | 1.017 (1.006–1.028) | <0.001 |
| Sex (men versus women) | 1.251 (0.918–1.706) | 0.155 |
| Ischaemic heart disease (yes versus no) | 1.270 (0.907–1.777) | 0.164 |
| Peripheral vascular disease (yes versus no) | 1.209 (0.873–1.673) | 0.253 |
| DR (yes versus no) | 1.506 (1.121–2.024) | 0.007 |
| Creatinine, mg/dL | 1.276 (1.224–1.330) | <0.001 |
| Proteinuria, g/24 h | 1.060 (1.032–1.088) | <0.001 |
| Treatment with RAASB (yes versus no) | 1.076 (0.791–1.466) | 0.641 |
| DN (DN versus NDRD/NDRD plus DN) | 1.900 (1.425–2.533) | <0.001 |
|
| ||
| Mortality | ||
|
| ||
| Model 2: Age, sex, ischaemic heart disease, peripheral vascular disease, DR, creatinine, proteinuria, treatment with RAASB and DN | ||
| Age, years | 1.039 (1.022–1.057) | <0.001 |
| Sex (men versus women) | 1.305 (0.870–1.957) | 0.198 |
| Ischaemic heart disease (yes versus no) | 1.003 (0.643–1.563) | 0.99 |
| Peripheral vascular disease (yes versus no) | 1.878 (1.252–2.818) | 0.002 |
| DR (yes versus no) | 1.191 (0.787–1.802) | 0.409 |
| Creatinine, mg/dL | 1.100 (1.023–1.182) | 0.01 |
| Proteinuria (g/24 h) | 1.019 (0.981–1.059) | 0.322 |
| Treatment with RAASB (yes versus no) | 1.165 (0.773–1.755) | 0.466 |
| DN (DN versus NDRD/NDRD plus DN) | 1.591 (1.096–2.308) | 0.015 |
HR, hazard ratio; CI, confidence interval. DR, diabetic retinopathy; RAASB, renin angiotensin system blockade; DN, diabetic nephropathy. Bold values: P<0.05.
Note: Bold values are with statistical significance.