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. 2019 Dec 22;13(3):468–472. doi: 10.1093/ckj/sfz166

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© The Author(s) 2019. Published by Oxford University Press on behalf of ERA-EDTA.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Anti-LRP2 nephropathy with concurrent kidney infiltration by LPL (Case 1). (A) Kidney biopsy with diffuse lymphoplasmacytic inflammatory infiltrate (periodic acid–Schiff, ×50). (B) Immune deposit along Bowman’s capsule (Jones, ×200). (C) Partially circumferential TBM immune deposit; tubules have acute injurious changes with attenuation of their cytoplasm and surrounding lymphoplasmacytic inflammation (Jones, ×400). (D) Granular TBM (arrows) and focal tubular brush border (arrowheads) staining for IgG. (E) Segmentally distributed subepithelial immune deposits (transmission electron microscopy, direct magnification ×1900). (F) Indirect immunofluorescence of patient’s serum reacting with normal kidney tubular brush borders (image courtesy of Dr Chris Larsen, Arkana Labs). (G) Scattered CD3-positive T-cell infiltrate (×50). (H) CD20-positive B cells, compatible with involvement by LPL (50×).