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. 2019 Dec 22;13(3):468–472. doi: 10.1093/ckj/sfz166

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© The Author(s) 2019. Published by Oxford University Press on behalf of ERA-EDTA.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Anti-LRP2 nephropathy with concurrent kidney infiltration by CLL/small lymphocytic lymphoma (SLL) (Case 2). (A) Wedge-shaped TBM immune deposit (Jones, ×400). (B) Widespread TBM. (C) Focal brush border staining for IgG. (D) Immune deposits embedded within TBM and bulging toward the luminal aspect (transmission electron microscopy, direct magnification ×590). (E) TBM immune deposits stained with LRP2 (image courtesy of Dr Nidia Messias, Arkana Labs). (F) Capsular and patchy interstitial infiltrate (periodic acid–Schiff, ×100) is composed of (G) CD20-positive B cells (×200) with (H) a kappa light chain restriction by in situ hybridization studies (×200); lambda light chain in situ hybridization is negative (inset, ×200), consistent with a monoclonal B-cell population.