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. 2020 Jun 5;48(13):7439–7453. doi: 10.1093/nar/gkaa478

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — AGO2:3′UTR binding clusters are associated with both up- and down-regulation of gene expression. (A) Distribution of gene expression changes for genes with significant AGO2:RNA-binding clusters. (B) Distribution of genes with more than one cluster. (C–F) Plot of gene expression changes versus cluster significance (C) AGO1, (D) AGO2, (E) AGO1/2 and (F) AGO1/2/3 knockout cells. For inclusion in analysis we required peaks to possess a P value <0.05 and a >4-fold enrichment in read number for wild-type verse AGO2 knockouts. See also Supplemental Figure S4.