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. 2020 Jun 5;48(13):7439–7453. doi: 10.1093/nar/gkaa478

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — AGO2 binding RNAseq read clusters for genes that are down regulated, do not significantly change, or are up-regulated. Examples of AGO2 binding clusters identified by AGO2 eCLIP-seq. Blue: Wild type cells. Red: AGO2 knockout cells. Orange: Input control. All clusters are within 3′-UTR regions unless labeled separately (MAL2, IL17RD). Representative AGO2-binding clusters for (A) down-regulated (MYC, MAL2, S100A14) (B) unchanged (EFNA1, TMEM184A, PRSS8) and (C) up-regulated genes (TMEM245, IL17RD, CYP2S1). For inclusion in analysis we required peaks to possess a P value <0.05 and a >4-fold enrichment in read number for wild-type verse AGO2 knockouts.