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. 2020 Jun 5;48(13):7439–7453. doi: 10.1093/nar/gkaa478

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Expression changes in AGO1, AGO2, AGO1/2 and AGO1/2/3 KO cells for genes with AGO2 protein binding clusters within their 3′-UTRs. (A, B) VENN diagram showing the the overlap among genes with AGO2:3′-UTR-binding sites and significant expression changes relative to wild-type cells for (A) increased or (B) decreased gene expression in wild-type versus knockout cells. (C) Heat map showing how the expression relative to wild-type cells changes in AGO1, AGO2, AGO1/2, and AGO1/2/3 cells for the 551 genes that have significant AGO protein:3′-UTR clusters and that are differentially expressed in AGO1/2/3 cells. (D) Heat map analysis showing relative changes in gene expression of the 179 AGO-associated genes that show significant expression changes in both AGO1/2 and AGO1/2/3 knockout cells.