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. 2020 Jun 11;48(13):7079–7098. doi: 10.1093/nar/gkaa485

Figure 6.

Figure 6.

Essentiality of RP Genes under CRISPR-Cas9 knockout in 558 cancer cell lines. CRISPR–Cas9 essentiality screen data for 74 RP genes for 558 cancer cell lines using the computational tool CERES (52). Genes with a dependency score (53,54) (gDS) greater than −1 are considered potentially non-essential. (A) Number of cell lines with gDS >−1 for each RP. Seven RPs had gDS > −1 in every cell line and 73 RPs had gDS >−1 in at least one cell line. (B) gDS profile of the RP genes in cell lines. Blue indicates gDS >−1 in the sample. (C) Distribution of number of RP genes with gDS >−1 across cell lines. Every cell line had at least 21 RP genes with gDS >−1. While 35 RPs with gDS > −1 was the most common, as many as 62 RP genes had gDS >−1 in a gastric cancer cell line (ACH-000167). (D) Number of RPs with gDS >−1 for cell lines stratified by cancer type.