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Schematic overview of in-cell Z-DNA 19F NMR experiments. (A) The comparison with the position of reference in vitro spectrum provides a reliable determination of intracellular Z-DNA. (B) Comparison of 19F NMR spectra for in vitro B-DNA, in vitro Z-DNA, in HeLa cell, in supernatant and difference spectrum between HeLa cell and supernatant.
