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3′-terminal 2′Ome of human miR-21-5p increases its stability. (A) The half-life of miR-21-5p and miR-26-5p in A549 cells and A549KO (HENMT1-knockout) cells. (B, C) Direct degradation of synthetic miR-21-5p/miR-21-5pCH3 and miR-26-5p/miR-26-5pCH3 by PNPT1 recombination protein in a time-dependent (B) and concentration-dependent (C) manner.
