TABLE. Multivariate analyses of Th1/Th2/Th17 cytokines associated with parasitaemia (binomial) and platelet indices.

Logistic regression of Pv-MAL patients in relation to parasitaemia				Linear regression predicting PDW between Pv-MAL patients and endemic controls
Mild parasitaemia (Reference)	Crude OR (CI 95%)	Adjusted OR (CI 95%)	p (LR-test)	Patients (Reference)	Estimates (CI 95%)	p value
Platelets	1.00 (0.99, 1.00)	1.00 (0.99, 1.01)	0.510	Platelets	-0.01 (-0.01, 0.01)	0.315
MPV	1.01 (0.84, 1.21)	1.01 (0.75, 1.37)	0.947	MPV	-0.03 (-0.27, 0.20)	0.770
PDW	0.97 (0.82, 1.16)	0.99 (0.81, 1.21)	0.93	PDW	1.44 (0.24, 2.63)	0.019
IL-1β	1.02 (0.99, 1.06)	1.03 (0.99, 1.07)	0.100	IL-1β	-0.03 (-0.05, -0.01)	0.047
IL-6	1.00 (0.99,1.00)	1.00 (0.99, 1.0001)	0.123	IL-6	-0.01 (-0.01, 0.01)	0.446
IL-8	1.00 (0.99, 1.01)	0.99 (0.98, 1.00)	0.197	IL-8	-0.01 (-0.01, 0.01)	0.801
TNF	1.00 (0.99, 1.01)	1.01 (0.99, 1.03)	0.312	TNF	0.01 (-0.01, 0.01)	0.371
IL-2	1.00 (0.98, 1.01)	0.99 (0.96, 1.01)	0.301	IL-2	-0.02 (-0.04, -0.01)	0.030
IL-10	1.00 (1.00, 1.00)	1.00 (1.00, 1.00)	0.029	IL-10	-0.01 (-0.01, 0.01)	0.573
IL-12p70	1.00 (0.99, 1.00)	1 (0.99, 1.00)	0.692	IL-12p70	-0.01 (-0.01, -0.01)	0.038
IFN-γ	1.00 (0.99, 1.00)	0.99 (0.99, 1.01)	0.900	IFN-γ	-0.01 (-0.01, 0.01)	0.413
IL-4	0.99 (0.99, 1.00)	0.99 (0.98, 1.00)	0.122	IL-4	0.01 (-0.01, 0.01)	0.833
IL-5	1.00 (0.96,1.04)	0.99 (0.94, 1.04)	0.773	IL-5	0.04 (-0.01, 0.08)	0.052
IL-17A	1.02 (1.00, 1.05)	1.03 (1.00, 1.07)	0.043	IL-17A	-0.01 (-0.03, 0.02)	0.712

CI: confidence interval; MPV: mean platelet volume; OR: odds ratio; PDW: platelet distribution width; Pv-MAL: Plasmodium vivax malaria.