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. 2020 Jul 17;21:489. doi: 10.1186/s12864-020-06909-z

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — The weighted gene correlation network analysis (WGCNA) for 24 RNA-Seq datasets. a 16 gene modules generated from WGCNA analysis. b Gene modules associated with four physiological stages (Post-partum Healthy, H_Post; Pre-partum Healthy, H_Pre; Post-partum Ketosis, K_Post; Pre-partum Ketosis, K_Pre) and seven blood bio-indicators (TC: total cholesterol, TG: total triglyceride, HDL: high-density lipoprotein, LDL: low-density lipoprotein, Ca: calcium, INS: insulin, BHBA: beta-hydroxybutyrate). The statistical significance of module-trait relationship is corrected for multiple testing using the FDR method, where “*” and “.” are for FDR < 0.05, < 0.1, respectively. The values in the brackets are the numbers of genes in corresponding modules. c The top significantly enriched biological processes for genes in the top four modules associated with the K_Post group. d The top significantly enriched tissue/cell types for genes in the top four modules associated with the K_Post group