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. 2020 Jul 17;20:320. doi: 10.1186/s12935-020-01410-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — HOTAIR directly interacted with miR-601 in BC. a The binding sites between HOTAIR-WT/MUT and miR-601 were obtained. b, c Dual-luciferase reporter assay was carried out to test the luciferase activity of HOTAIR-WT/MUT after cells were transfected with miR-601 mimic or miR-NC. d RIP assay results indicated that the enrichment of HOTAIR was increased in RIP-Ago2 of BC cells transfected with miR-601. e, f MiR-601 expression was remarkably downregulated in BC tissues and cells compared to adjacent normal tissues and MCF-10A cells, respectively. g The negative relation between HOTAIR and miR-601 was analyzed by Pearson correlation analysis. h The HOTAIR overexpression efficiency was detected by qRT-PCR. i The expression of miR-601 was measured by qRT-PCR to evaluate the effect of HOTAIR overexpression and knockdown on miR-601 expression. *P < 0.05