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. 2020 Jul 16;10:11842. doi: 10.1038/s41598-020-68804-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Administration of recombinant progranulin decreased deterioration of cardiac dysfunction after myocardial ischemia–reperfusion injury in rabbits. (A) The positive values of the first derivative in left ventricular pressure (dP/dt) and (B) the negative dP/dt were determined by cardiac catheterization 2 weeks after myocardial ischemia/reperfusion (I/R). (C) Left ventricular internal diameter at diastole (LVIDd), (D) left ventricular internal diameter at systole (LVIDs), (E) ejection fraction (EF), and (F) fractional shortening (FS) were measured by echocardiography analysis. The administration of recombinant progranulin significantly ameliorated the deterioration of + dP/dt, LVIDd, LVIDs, EF and FS compared with vehicle-treated group. Data are the means ± SEM. (n = 3–7) ^*p < 0.05 versus vehicle-treated group (A, B; two-tailed Student's t-test, C–F; one-tailed Student's t-test).