Table 2.

Comparison between complete and incomplete silencing FMR1 mRNA in FM-only males and PM/FM mosaics on maladaptive behaviours.

	FM-only with complete silencing (N = 19)		FM-only with incomplete silencing (N = 29)		PM/FM mosaic (N = 14)		p1	p2	p3	p4
	M	SD	M	SD	M	SD
Irritability	16.9	11.8	14.7	9.36	8.07	5.36	0.045	0.350	0.014*	0.066
Lethargy	5.79	3.78	6.93	4.64	4.93	3.75	0.472	0.414	0.700	0.252
Stereotypy	6.37	5.14	4.28	3.45	3.93	4.20	0.132	0.055	0.139	0.884
Hyperactivity	13.0	8.37	10.2	7.04	7.29	5.90	0.082	0.094	0.034	0.424
Inappropriate speech	6.11	2.38	4.76	3.09	2.21	2.52	< 0.001*	0.119	< 0.001*	0.002*
Social avoidance	3.95	3.19	3.69	2.02	2.93	3.32	0.595	0.732	0.318	0.442
ABC total	52.1	27.4	44.5	18.6	29.4	19.8	0.020	0.158	0.005*	0.074
ABC UI	0.57	0.19	0.60	0.14	0.72	0.13	0.030	0.415	0.010*	0.037

P-values highlighted in bold were significant prior to adjustment for multiple comparisons.

Comparisons were conducted using analysis of covariance, adjusted for age; FM full mutation, PM premutation, M mean, SD standard deviation, ABC aberrant behavior checklist, UI utility index.

p-value (p) for comparing the means between ¹three groups; ²FM-only with complete silencing and FM-only with incomplete silencing; ³FM-only with compete silencing and PM/FM Mosaic; ⁴FM-only with incomplete silencing and PM/FM mosaic.

*p-value remained < 0.05 after adjusting for multiple comparison of the three pairwise tests using Bonferroni correction method.