Table 1.
Summary of routine blood test parameters of six groups of β-thalassaemic mice before and after transplantation from week 0 to week 5 after nonmyeloablative treatment
Weight (g) | RBC (1012/l) | HB (g/l) | HCT (%) | |
0 week | ||||
α-MEM group (n = 3) | 19.30 ± 0.71 | 7.52 ± 0.58 | 92.67 ± 5.51 | 31.07 ± 2.37 |
UCBC group (n = 3) | 18.77 ± 1.68 | 7.89 ± 0.71 | 98.00 ± 8.00 | 32.33 ± 3.55 |
hESC group (n = 3) | 19.70 ± 0.90 | 7.69 ± 0.45 | 94.33 ± 5.13 | 31.77 ± 1.44 |
niPSC group (n = 3) | 19.77 ± 0.68 | 7.28 ± 0.45 | 89.00 ± 4.58 | 30.43 ± 1.61 |
piPSC group (n = 3) | 18.93 ± 1.24 | 7.38 ± 0.39 | 90.00 ± 4.36 | 31.13 ± 0.50 |
ciPSC group (n = 3) | 20.00 ± 1.39 | 7.46 ± 0.25 | 92.00 ± 1.73 | 31.05 ± 0.78 |
1 week | ||||
α-MEM group (n = 3) | 20.80 ± 0.85 | 2.96 ± 0.13 | 34.33 ± 4.16 | 18.17 ± 3.84 |
UCBC group (n = 3) | 20.60 ± 1.50 | 2.99 ± 0.45 | 37.67 ± 5.03 | 12.50 ± 2.36 |
hESC group (n = 3) | 21.10 ± 0.72 | 2.77 ± 0.53 | 33.67 ± 6.66 | 11.63 ± 2.91 |
niPSC group (n = 3) | 21.00 ± 0.36 | 2.95 ± 0.53 | 35.00 ± 5.29 | 7.77 ± 2.70 |
piPSC group (n = 3) | 20.80 ± 0.70 | 2.70 ± 0.26 | 32.50 ± 2.12 | 14.25 ± 1.63 |
ciPSC group (n = 3) | 20.93 ± 1.88 | 3.20 ± 0.52 | 39.67 ± 6.51 | 15.53 ± 4.45 |
2 weeks | ||||
α-MEM group (n = 3) | 21.55 ± 1.63 | 5.11 ± 0.69 | 65.50 ± 9.19 | 33.00 ± 12.02 |
UCBC group (n = 3) | 21.90 ± 0.85 | 6.04 ± 0.73 | 74.00 ± 11.31 | 33.45 ± 7.00 |
hESC group (n = 3) | 20.13 ± 2.53 | 5.47 ± 0.42 | 68.50 ± 3.54 | 22.13 ± 13.86 |
niPSC group (n = 3) | 19.17 ± 3.41 | 5.83 ± 0.40 | 70.00 ± 5.66 | 18.00 ± 20.38 |
piPSC group (n = 3) | 22.45 ± 0.07 | 5.28 ± 0.35 | 65.00 ± 5.66 | 32.65 ± 2.76 |
ciPSC group (n = 3) | 22.27 ± 2.16 | 6.03 ± 0.35 | 73.00 ± 5.66 | 25.30 ± 7.91 |
3 weeks | ||||
α-MEM group (n = 3) | 21.60 ± 0.99 | 6.08 ± 0.28 | 74.50 ± 3.54 | 33.30 ± 0.57 |
UCBC group (n = 3) | 22.30 ± 0.85 | 6.57 ± 0.09 | 81.00 ± 2.83 | 28.35 ± 0.21 |
hESC group (n = 3) | 20.70 ± 1.13 | 6.77 ± 0.62 | 83.50 ± 4.95 | 30.85 ± 3.18 |
niPSC group (n = 3) | 21.00 ± 1.27 | 6.58 ± 0.47 | 79.00 ± 8.49 | 32.45 ± 3.04 |
piPSC group (n = 3) | 20.90 ± 0.14 | 6.06 ± 0.37 | 73.00 ± 7.07 | 30.40 ± 2.55 |
ciPSC group (n = 3) | 21.50 ± 1.37 | 6.42 ± 0.42 | 78.67 ± 6.43 | 30.20 ± 1.08 |
4 weeks | ||||
α-MEM group (n = 3) | 21.40 ± 1.70 | 6.61 ± 0.46 | 82.50 ± 3.54 | 29.60 ± 0.14 |
UCBC group (n = 3) | 22.80 ± 1.56 | 7.09 ± 0.64 | 86.50 ± 4.95 | 30.40 ± 3.11 |
hESC group (n = 3) | 21.05 ± 0.78 | 6.97 ± 0.70 | 87.50 ± 4.95 | 31.30 ± 2.40 |
niPSC group (n = 3) | 21.20 ± 1.41 | 6.97 ± 1.52 | 85.50 ± 17.68 | 31.05 ± 7.00 |
piPSC group (n = 3) | 20.05 ± 0.21 | 6.92 ± 0.28 | 85.00 ± 5.66 | 30.00 ± 0.28 |
ciPSC group (n = 3) | 21.17 ± 1.61 | 6.42 ± 0.17 | 79.33 ± 2.31 | 29.30 ± 1.61 |
5 weeks | ||||
α-MEM group (n = 3) | 23.95 ± 1.06 | 6.78 ± 0.50 | 83.00 ± 5.66 | 30.10 ± 0.14 |
UCBC group (n = 3) | 23.10 ± 0.07 | 6.91 ± 0.21 | 84.00 ± 1.41 | 28.65 ± 1.20 |
hESC group (n = 3) | 23.45 ± 1.34 | 6.51 ± 0.08 | 78.50 ± 0.71 | 28.00 ± 0.71 |
niPSC group (n = 3) | 23.55 ± 1.34 | 6.91 ± 1.03 | 86.50 ± 14.85 | 30.00 ± 4.95 |
piPSC group (n = 3) | 22.25 ± 0.21 | 6.39 ± 0.22 | 79.00 ± 4.24 | 27.00 ± 0.57 |
ciPSC group (n = 3) | 23.87 ± 1.66 | 6.58 ± 0.79 | 81.33 ± 10.02 | 29.23 ± 2.41 |
MCV (fl) | MCH (pg) | MCHC (g/l) | RET% | |
0 week | ||||
α-MEM group (n = 3) | 41.27 ± 0.35 | 12.33 ± 0.21 | 298.67 ± 4.93 | 14.64 ± 2.06 |
UCBC group (n = 3) | 40.97 ± 1.01 | 12.43 ± 0.12 | 304.00 ± 9.17 | 12.99 ± 3.18 |
hESC group (n = 3) | 41.33 ± 0.57 | 12.30 ± 0.17 | 296.67 ± 3.21 | 13.16 ± 4.13 |
niPSC group (n = 3) | 41.77 ± 0.38 | 12.23 ± 0.21 | 292.33 ± 2.89 | 13.14 ± 3.37 |
piPSC group (n = 3) | 42.30 ± 1.65 | 12.23 ± 0.12 | 289.00 ± 10.15 | 14.99 ± 6.27 |
ciPSC group (n = 3) | 43.00 ± 1.51 | 12.33 ± 0.15 | 287.00 ± 13.00 | 18.13 ± 1.76 |
1 week | ||||
α-MEM group (n = 3) | 47.07 ± 3.75 | 12.67 ± 0.29 | 270.00 ± 20.52 | 8.18 ± 4.05 |
UCBC group (n = 3) | 41.60 ± 1.71 | 12.60 ± 0.50 | 304.00 ± 22.61 | 4.00 ± 0.64 |
hESC group (n = 3) | 41.67 ± 3.00 | 12.17 ± 0.29 | 292.33 ± 18.58 | 3.88 ± 2.23 |
niPSC group (n = 3) | 40.90 ± 3.15 | 12.43 ± 0.35 | 305.00 ± 22.61 | 3.85 ± 1.15 |
piPSC group (n = 3) | 42.95 ± 1.34 | 12.50 ± 0.00 | 292.00 ± 8.49 | 4.42 ± 0.18 |
ciPSC group (n = 3) | 47.83 ± 6.25 | 12.37 ± 0.06 | 261.67 ± 33.65 | 8.40 ± 5.98 |
2 weeks | ||||
α-MEM group (n = 3) | 50.45 ± 3.61 | 12.30 ± 0.71 | 243.50 ± 3.54 | 54.45 ± 4.88 |
UCBC group (n = 3) | 49.70 ± 2.69 | 12.15 ± 0.21 | 245.00 ± 18.38 | 34.25 ± 19.16 |
hESC group (n = 3) | 54.40 ± 1.35 | 12.07 ± 0.87 | 221.67 ± 10.21 | 40.75 ± 19.76 |
niPSC group (n = 3) | 51.37 ± 3.86 | 11.30 ± 1.18 | 221.00 ± 31.95 | 30.13 ± 17.03 |
piPSC group (n = 3) | 52.10 ± 4.95 | 12.50 ± 0.00 | 241.00 ± 22.63 | 56.30 ± 11.88 |
ciPSC group (n = 3) | 54.10 ± 3.04 | 12.33 ± 0.15 | 227.67 ± 12.90 | 42.37 ± 15.43 |
3 weeks | ||||
α-MEM group (n = 3) | 47.95 ± 6.29 | 12.20 ± 0.14 | 256.50 ± 31.82 | 34.16 ± 28.91 |
UCBC group (n = 3) | 43.15 ± 0.92 | 12.35 ± 0.21 | 285.50 ± 12.02 | 19.07 ± 1.07 |
hESC group (n = 3) | 45.55 ± 0.49 | 12.35 ± 0.35 | 271.50 ± 12.02 | 19.72 ± 1.41 |
niPSC group (n = 3) | 49.60 ± 8.20 | 12.00 ± 0.42 | 246.00 ± 49.50 | 30.98 ± 23.50 |
piPSC group (n = 3) | 43.95 ± 1.63 | 12.45 ± 0.21 | 283.50 ± 14.85 | 20.51 ± 1.66 |
ciPSC group (n = 3) | 47.23 ± 2.07 | 12.23 ± 0.29 | 259.67 ± 17.01 | 26.14 ± 6.27 |
4 weeks | ||||
α-MEM group (n = 3) | 44.95 ± 3.32 | 12.50 ± 0.28 | 278.50 ± 13.44 | 12.33 ± 0.04 |
UCBC group (n = 3) | 42.85 ± 0.49 | 12.20 ± 0.42 | 285.00 ± 12.73 | 15.94 ± 5.49 |
hESC group (n = 3) | 44.05 ± 0.21 | 12.35 ± 0.21 | 280.00 ± 5.66 | 14.27 ± 6.46 |
niPSC group (n = 3) | 44.55 ± 0.35 | 12.30 ± 0.14 | 276.00 ± 5.66 | 11.85 ± 3.85 |
piPSC group (n = 3) | 43.35 ± 1.34 | 12.30 ± 0.28 | 283.50 ± 16.26 | 16.03 ± 0.21 |
ciPSC group (n = 3) | 45.63 ± 1.36 | 12.37 ± 0.06 | 271.33 ± 8.50 | 20.44 ± 8.75 |
5 weeks | ||||
α-MEM group (n = 3) | 43.55 ± 4.88 | 12.25 ± 0.07 | 276.00 ± 19.80 | 12.13 ± 2.93 |
UCBC group (n = 3) | 41.45 ± 0.49 | 12.15 ± 0.21 | 293.50 ± 7.78 | 10.60 ± 2.10 |
hESC group (n = 3) | 43.00 ± 0.57 | 12.05 ± 0.21 | 280.50 ± 9.19 | 10.25 ± 1.62 |
niPSC group (n = 3) | 43.35 ± 0.64 | 12.50 ± 0.28 | 288.50 ± 2.12 | 29.83 ± 31.07 |
piPSC group (n = 3) | 42.30 ± 0.57 | 12.35 ± 0.21 | 292.50 ± 9.19 | 12.98 ± 4.16 |
ciPSC group (n = 3) | 44.57 ± 1.72 | 12.33 ± 0.06 | 277.67 ± 11.50 | `13.38 ± 0.92 |
Values represent mean ± SD. RBC red blood cell count, HB haemoglobin, HCT haematocrit, MCV mean corpuscular volume, MCH mean corpuscular haemoglobin, MCHC mean corpuscular haemoglobin concentration, RET reticulocyte count