. 2020 Jul 16;21:487. doi: 10.1186/s12864-020-06878-3

Table 1.

Summary of the tapeworm proteins selected as being strobilation-related. The presence of orthologues in species of other taxa is indicated by an ‘x’. Differential expression of the corresponding genes in larval versus adult stages is indicated by an arrow, with up (↑) and down (↓) arrows indicating up and down-regulation, respectively, in the adult (strobilated) stage; a dot (●) indicates that there is no differential expression between these stages. Abbreviations of protein names are as follows: bone morphogenetic protein 2 (BMP-2); Cyclin-G-associated kinase (GAK); Groucho protein (Groucho); Homeobox protein B4a (HoxB4a); Lim homeobox protein lhx1 (LHX1); membrane-associated guanylate kinase protein 2 (MAGI2); serine:threonine protein kinase Mark2 (Mark2); atrial natriuretic peptide receptor 1 (NPR1); RNA binding motif single stranded interacting (RBMS); serine:threonine protein kinase (Ser:Thr kinase); mothers against decapentaplegic homolog 4-like (SMAD4); and Pangolin J (TCF/LCF). Proteins of unknown function (UF) are identified by numbers according to the corresponding orthogroups

Protein name	Platyhelminthes										Annelida	Mollusca		Nematoda
	Trematoda					Cestoda								Nematoda
	C. sinensis	O. viverrini	S. haematobium^a	S. japonicum	S. mansoni^b	E. granulosus	E. multilocularis^c	H. microstoma^d	M. corti^e	T. solium	H. robusta	L. gigantea	C. elegans	G. pallida	H. conturtus	O. volvulus	S. ratti	T.muris
BMP-2						x	↑	●	●	x
GAK		x	x	x	●	x	↓	●	●	x	x
Groucho	x		●	x		x	↓	●	●	x	x	x	x			x		x
HoxB4a						x	●	↓	●	x
LHX1						x	↓	●	●	x
MAGI2						x	↑	●	●	x
Mark2						x	↓	●	●	x	x	x	x			x	x	x
NPR1			x		●	x	↑	●	●	x		x
RBMS						x	↑	●	●	x	x
Ser:Thr kinase						x	↓	●	●	x	x	x
SMAD4			●			x	↓	●	●	x	x	x		x		x	x	x
TCF/LCF						x	↓	●	●	x	x
UF1		x				x	↑	↑	●	x
UF2						x	●	↑	●	x
UF3						x	↑	●	↑	x
UF4						x	↓	●	●	x
UF5						x	↑	●	●	x
UF6						x	●	●	↓	x
UF7						x	↑	●	●	x
UF8						x	↑	↑	●	x
UF9						x	↑	●	●	x
UF10						x	↓	●	●	x
UF11						x	↓	●	●	x
UF12						x	●	●	↑	x
UF13						x	●	↑	●	x
UF14						x	↑	↑	●	x
UF15	x	x			●	x	↑	●	●	x	x	x
UF16			●			x	↓	●	●	x
UF17						x	↓	●	●	x
UF18	x	x	↓		●	x	●	●	↑	x
UF19	x	x				x	↑	●	●	x
UF20	x				●	x	↑	●	↑	x
UF21		x				x	↑	●	●	x
UF22						x	↓	●	●	x

^aS. haematobium expressed sequence tag libraries analysis (Young et al. 2012]) [20]

^bS. mansoni RNA-seq analysis (Protasio et al. 2012) [21]

^cE. multilocularis RNA-seq analysis (Tsai et al. 2013) [12]

^dH.microstoma RNA-seq analysis (Tsai et al. 2013) [12]

^eM. corti RNA-seq data analysis (Basika et al. 2019) [16]