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. 2020 Jul 16;10:11814. doi: 10.1038/s41598-020-68775-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Proteins targeted by the compounds. Human liver cancer cells (Mahlavu) were treated with the IC₅₀ concentrations of the selected compounds or DMSO control for 24 h. (A) Western blot analysis showed that Akt protein is inhibited in liver cancer cells treated with the compounds resulting in alterations of p21 and NFkB proteins. (B–D) Quantification of the results using ImageJ software. (E) Schematic representation of the molecular mechanism of action of the compounds. Blocked signaling is crossed.