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. 2020 Jul 17;16:247. doi: 10.1186/s12917-020-02459-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Paw withdrawal test before streptozotocin (STZ) treatment and two days prior to sciatic nerve block and tail flick test two days prior to sciatic nerve block in STZ-induced diabetic (●) (n = 18) and nondiabetic (■) (n = 18) mice. *P < 0.0001 vs. nondiabetic mice prior to sciatic block and diabetic and nondiabetic mice prior to STZ treatment (one-way ANOVA); #P < 0.001 vs. nondiabetic mice (independent t-test)